"How is Gamora?"

In Avengers: Infinity War, a small group of Avengers run into a group called the Guardians of the Galaxy. Both groups mistake each other for their mutual enemy, Thanos, who had taken Gamora, a member of the Guardians of the Galaxy, captive. During a stalemate in the ensuing fight, leader of the Guardians demands, "Where is Gamora?" Not knowing who Gamora even is, the leader of the Avengers says, "I'll do you one better. Who is Gamora?" And Drax, a member of the Guardians whose frequent misunderstanding of language often adds unintended levity, says "I'll do you one better. Why is Gamora?" Personally, I think it would have been better to have someone ask, "How is Gamora?"

At the time, Gamora was in mortal peril, but danger is rarely the only problem when one is alone. A person who is alone may tend to feel lonely, isolated, or disconnected. They may feel an absence of human connection and love. Sometimes, being alone isn't the source of the problem(s), but a symptom. Sometimes, people want to be alone to escape the negative feelings they have around other people. Either way, a person being alone is a sign that something may be wrong. Maybe something is wrong because they're alone, or maybe they're alone because something is wrong, maybe neither, or maybe both.

So, when someone is alone, and you have a close enough of a connection to them that reaching out to them wouldn't make the possibly existing problem worse, it may be kind to reach out to them and ask them how they're doing. Maybe they're facing problems because they're alone, or maybe they're choosing to be alone because they were facing problems. If you care about their problems, it is sometimes kind to reach out to those who are or feel alone.